PAI1 PAI1 (plasminigen activator inhibitor-1), Serpine1 (serpin peptidase inhibitor clade E member 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
Plasma Cell
Platelet
Endothelial Cell
Fibrosarcoma cell
Hepatoma Cell
45 / 45

Expression
PAI1 is expressed in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the serpin family.

PAI1 is a acid-stable 402 aa glycoprotein.  PAI1 is a secreted protein.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH PAI1: No information.

Function
PAI1 acts as "bait" for tissue plasminoigen activator, urokinase (u-PA) and protein C.  Its rapid interaction with tissue-type (TPA) may function as a major control point in the regulation of fibrinolysis.  PAI1 is inacrivated by proteolytic attack of u-PA and TPA cleaving the 369(R)-370(M) bond.  Vascular endothelial cells may be the primary site of synthesis of plasma PAI.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELERVANCE AND FUNCTION OF PAI1 IN INTACT ANIMAL

Defects in SERPINE are the cause of PAI1 deficiency.  This deficiency is characterized by abnormal bleeding due to SERPINE defect in the plasma.  High concentrations of PAI1 have been associated with thrombophilia, an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PAI1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY PAI1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 5054P05121
Antibodies

Revised June 25, 2008


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