|PAI1||PAI1 (plasminigen activator inhibitor-1), Serpine1 (serpin peptidase inhibitor clade E member 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|45 / 45|
|PAI1 is expressed in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.|
|MOLECULAR FAMILY NAME: Belongs to the serpin family.|
PAI1 is a acid-stable 402 aa glycoprotein. PAI1 is a secreted protein.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH PAI1: No information.|
|PAI1 acts as "bait" for tissue plasminoigen activator, urokinase (u-PA) and protein C. Its rapid interaction with tissue-type (TPA) may function as a major control point in the regulation of fibrinolysis. PAI1 is inacrivated by proteolytic attack of u-PA and TPA cleaving the 369(R)-370(M) bond. Vascular endothelial cells may be the primary site of synthesis of plasma PAI.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELERVANCE AND FUNCTION OF PAI1 IN INTACT ANIMAL
Defects in SERPINE are the cause of PAI1 deficiency. This deficiency is characterized by abnormal bleeding due to SERPINE defect in the plasma. High concentrations of PAI1 have been associated with thrombophilia, an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PAI1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY PAI1: No information.
Database accession numbers
Revised June 25, 2008