PORIMIN PORIMIN (pro-oncosis receptor inducing membrane injury), TMEM123 (transmembrane protein 123)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Ubiquitous
Keratinocyte
Thyroid
Kidney
Uterus
Trachea
Liver
Carcinoma Cell
Lung
Tumor Cell

Expression
PORIMIN expression is ubiquitous and relatively high levels in trachea, fetal kidney, uterus, thyroid gland, adult liver, 2 tumor cell lines, colorectal adenocarcinoma and lung carcinoma.  Expression is found in keratinocytes but not in ovary.

Structure
MOLECULAR FAMILY NAME:  Belongs to the CD164 family.

PORIMIN is a single-pass type-1 189 aa glycoprotein.  It contains an extracellular domain which contains many O-linked and 7-linked glycosylation sites, a transmembrane domain and a cytoplasmic domain. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION

PORIMIN has N-linked and O-linked glycosylation sites and these site define PORIMIN as a member of the mucin family.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH PORIMIN: No information.

Function

PORIMIN is a member of cell membrane associated mucin family and is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in the extracellular domain, similar to a broadly defined category of proteins termed mucins.  PORIMIN antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.  Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation.  PORIMIN is proposed to function as a cell surface receptor that mediates cell death characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF PORIMIN IN INTACT ANIMAL: No information.



Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PORIMIN: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY PORIMIN: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez114908Q8N131
Antibodies

Revised June 25, 2008


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