|PORIMIN||PORIMIN (pro-oncosis receptor inducing membrane injury), TMEM123 (transmembrane protein 123)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|PORIMIN expression is ubiquitous and relatively high levels in trachea, fetal kidney, uterus, thyroid gland, adult liver, 2 tumor cell lines, colorectal adenocarcinoma and lung carcinoma. Expression is found in keratinocytes but not in ovary.|
|MOLECULAR FAMILY NAME: Belongs to the CD164 family.|
PORIMIN is a single-pass type-1 189 aa glycoprotein. It contains an extracellular domain which contains many O-linked and 7-linked glycosylation sites, a transmembrane domain and a cytoplasmic domain.
Alternative splicing yields 2 different isoforms.
PORIMIN has N-linked and O-linked glycosylation sites and these site define PORIMIN as a member of the mucin family.
|LIGANDS AND MOLECULES ASSOCIATED WITH PORIMIN: No information.|
PORIMIN is a member of cell membrane associated mucin family and is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in the extracellular domain, similar to a broadly defined category of proteins termed mucins. PORIMIN antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. PORIMIN is proposed to function as a cell surface receptor that mediates cell death characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PORIMIN: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY PORIMIN: No information.
Database accession numbers
Revised June 25, 2008