PTDSR PTDSR (Phosphatidylserine receptor), JmjC (jumonji domain)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
Epithelial Cell
Heart
Skeletal muscle
Kidney
Pancreas

Expression
PTDSR is highly expressed in the heart, skeletal muscle and kidney.  Expression is moderate or low levels in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary.  Up-regulation occurs in patients with chronic pancreatitis and in nursing thymic epithelial cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the phosphatidylserine receptor family.

PTDSR is a 427 aa glycoprotein.  It contains an extracellular domain which contains a jumojiC domain, a transmembrane domain and a cytoplasmic domain.  It contains a series of potential O-linked glycosylation sites in the C terminus.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.

POST-TRANSLATIONAL MODIFICATION

PTDSR has a series of potential O-linked glycosyation sites.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH PTDSR: No information.

Function
PTDSR is required during embryogenesis and differentiation of multiple organs during embryogenesis.  It probably acts as a key regulator of hematopoietic differentiation but may not be required for apoptotic cell clearance by macrophages but seems to be necessary for the regulation of macrophage cytokine responses.  It is upregulated upon cytokine treatment but not upon TNF-α treatment.
 
BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF PTDSR IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OFG PTDSR: No infiormation.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY PTDSR: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez 23210Q6NYC1
Antibodies

Revised June 25, 2008


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