|PTDSR||PTDSR (Phosphatidylserine receptor), JmjC (jumonji domain)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|PTDSR is highly expressed in the heart, skeletal muscle and kidney. Expression is moderate or low levels in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulation occurs in patients with chronic pancreatitis and in nursing thymic epithelial cells.|
|MOLECULAR FAMILY NAME: Belongs to the phosphatidylserine receptor family.|
PTDSR is a 427 aa glycoprotein. It contains an extracellular domain which contains a jumojiC domain, a transmembrane domain and a cytoplasmic domain. It contains a series of potential O-linked glycosylation sites in the C terminus.
Alternative splicing yields 3 different isoforms.
PTDSR has a series of potential O-linked glycosyation sites.
|LIGANDS AND MOLECULES ASSOCIATED WITH PTDSR: No information.|
|PTDSR is required during embryogenesis and differentiation of multiple organs during embryogenesis. It probably acts as a key regulator of hematopoietic differentiation but may not be required for apoptotic cell clearance by macrophages but seems to be necessary for the regulation of macrophage cytokine responses. It is upregulated upon cytokine treatment but not upon TNF-α treatment.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF PTDSR IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OFG PTDSR: No infiormation.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY PTDSR: No information.
Database accession numbers
Revised June 25, 2008