PTPRF 

PTPRF (protein tyrosine phosphatase, receptor type F), LAR (leukocyte antigen-related tyrosine phosphatase)

Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein

Expression


Structure
MOLECULAR FAMILY NAME: Belongs to the protein tyrosine phosphatase family.

PTPRF is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains 3 Ig-like C2-type domains and 9 fibronectin type-3 domains that are homologous to the neural cellular adhesion molecule (CD56, NCAM), a transmembrane domain and a cytoplasmic domain which contains 2 tandem catalytic tyrosine protein phosphatase domains which represents a receptor-type PTP.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms which encodes distinct proteins.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH PTPRF: No information.

Function

PTPRF is a member of the tyrosine phosphatase (PTP) family.  PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle and oncogenic transformation.  The human LAR molecule closely resembles cell adhesion molecules which suggests that it may be involved in the regulation of phosphotyrosine levels through cell-cell or cell-matrix interactions.  Regulation of epithelial cell-cell contacts are at adherents junctions as well as in the control of β-catenin signaling.  PTPRF is a possible adhesion receptor.  It processes an intrinsic protein tyrosine phosphatase activity (PTPase).  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF PTPRF IN INTACT ANIMAL

An expression level of this protein was found in the insulin-responsive tissue of obese, insulin resistant individuals, and may contribute to the pathogenesis of insulin resistance.



Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PTPRF: No information.

SUBSTRATES:  No information.

ENZYMES WHICH MODIFY PTPRF: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 5792P10586
Antibodies

Revised June 25, 2008


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