PTPRF (protein tyrosine phosphatase, receptor type F), LAR (leukocyte antigen-related tyrosine phosphatase)
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|MOLECULAR FAMILY NAME: Belongs to the protein tyrosine phosphatase family.|
PTPRF is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 3 Ig-like C2-type domains and 9 fibronectin type-3 domains that are homologous to the neural cellular adhesion molecule (CD56, NCAM), a transmembrane domain and a cytoplasmic domain which contains 2 tandem catalytic tyrosine protein phosphatase domains which represents a receptor-type PTP.
Alternative splicing yields 2 different isoforms which encodes distinct proteins.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH PTPRF: No information.|
PTPRF is a member of the tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle and oncogenic transformation. The human LAR molecule closely resembles cell adhesion molecules which suggests that it may be involved in the regulation of phosphotyrosine levels through cell-cell or cell-matrix interactions. Regulation of epithelial cell-cell contacts are at adherents junctions as well as in the control of β-catenin signaling. PTPRF is a possible adhesion receptor. It processes an intrinsic protein tyrosine phosphatase activity (PTPase). The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF PTPRF: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY PTPRF: No information.
Database accession numbers
Revised June 25, 2008