|SLAMF6||SLAMF6 (SLAM family member 6), LY108|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|SLAMF6 is expressed by all resting and activated NK cells, and T and B lymphocytes,|
|MOLECULAR FAMILY NAME: Belongs the immunoglobulin gene family.|
SLAMF6 is a single-pass type-1 332 aa glycoprotein. It contains a leader sequence, a 204 aa extracellular domain which contains 1 Ig-like domain and 7 potential N-linked glycosylation sites, a transmembrane domain which lacks charged amino acids and a 83 aa cytoplasmic domain which has 2 TxYxxV/I motifs and 1 ITIM motif. SLAMF6 belongs to the CD2 subfamily of the Ig superfamily.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
SLAMF6 has 7 potential N-linked glycosylation sites and is phosphorylated.
|LIGANDS AND MOLECULES ASSOCIATED WITH SLAMF6: No information.|
|SLAMF6 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein SH2D1A as well as with SH2 domain-containing phosphatases (SHPs). SLAMF6 triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. It may function as a coreceptor in the process of NK cell activation. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF SLAMF6 IN INTACT ANTIMAL
It can mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. SLAMF6 has been linked to a variety of lupus-related diseases such as antinuclear antibodies, splenomegaly and glomerulonephritis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SLAMF6: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY SLAMF6: No information.
Database accession numbers
Revised June 25, 2008