SLAMF6 SLAMF6 (SLAM family member 6), LY108
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
NK Cell
T Lymphocyte
B Lymphocyte

Expression
SLAMF6 is expressed by all resting and activated NK cells, and T and B lymphocytes,

Structure
MOLECULAR FAMILY NAME: Belongs the immunoglobulin gene family.

SLAMF6 is a single-pass type-1 332 aa glycoprotein.  It contains a leader sequence, a 204 aa extracellular domain which contains 1 Ig-like domain and 7 potential N-linked glycosylation sites, a transmembrane domain which lacks charged amino acids and a 83 aa cytoplasmic domain which has 2 TxYxxV/I motifs and 1 ITIM motif.  SLAMF6 belongs to the CD2 subfamily of the Ig superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

SLAMF6 has 7 potential N-linked glycosylation sites and is phosphorylated.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH SLAMF6: No information.

Function
SLAMF6 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein SH2D1A as well as with SH2 domain-containing phosphatases (SHPs).  SLAMF6 triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors.  It may function as a coreceptor in the process of NK cell activation. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF SLAMF6 IN INTACT ANTIMAL

It can mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.  SLAMF6 has been linked to a variety of lupus-related diseases such as antinuclear antibodies, splenomegaly and glomerulonephritis.


Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SLAMF6: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY SLAMF6: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez114836Q96DU3
Antibodies

Revised June 25, 2008


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