|SLAMF8||SLAMF8 (SLAM family member 8), BLAME (B lymphocyte activator macrophage expressed)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|SLAMF8 is expressed in lymph nodes, spleen, thymus and bone marrow.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
SLAMF8 is a single-pass type-1 285 aa glycoprotein. It contains a leader sequence, a 212 aa extracellular domain which contains 1 Ig-like C2-type domain and a N-terminal Ig-like V-type fold without disulfide bonds, a transmembrane domain and cytoplasmic domain. SLAMF8 encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. SLAMF8 is found in a region of chromosome 1 containing many CD2 genes.
Alternative splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULES ASSOCIATED WITH SLAMF8: No information.
|SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B cell receptor.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF SLAMF8 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SLAMF8: No information.
SUBSTRATES: No information.
ENZYME WHICH MODIFY SLAMF8: No information.
Database accession numbers
Revised June 25, 2008