SLAMF8 SLAMF8 (SLAM family member 8), BLAME (B lymphocyte activator macrophage expressed)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Lymph Node
Spleen
Thymus
Bone Marrow

Expression
SLAMF8 is expressed in lymph nodes, spleen, thymus and bone marrow.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

SLAMF8 is a single-pass type-1 285 aa glycoprotein.  It contains a leader sequence, a 212 aa extracellular domain which contains 1 Ig-like C2-type domain and a N-terminal Ig-like V-type fold without disulfide bonds, a transmembrane domain and cytoplasmic domain.  SLAMF8 encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation.  SLAMF8 is found in a region of chromosome 1 containing many CD2 genes.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH SLAMF8: No information.



Function
SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B cell receptor.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF SLAMF8 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF SLAMF8: No information.

SUBSTRATES: No information.

ENZYME WHICH MODIFY SLAMF8: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez56833Q9P0V8
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University