|TFR2||TFR2 (transferrin receptor 2)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|TFR1 is expressed in the liver. The α isoform is expressed in spleen, lung, muscle, prostate and peripheral mononuclear cells and the β isoform is weakly expressed in all tissues.|
MOLECULAR FAMILY NAME: Belongs to the peptidase M28 family.
|LIGANDS AND MOLECULES ASSOCIATED WITH TFR2: No information.|
|TFR2 mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. It may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF TFR2 IN INTACT ANIMAL
Defects in TFR2 cause a hereditary hemochromatosis type-3 (HFE3) which results in iron overload and can cause complications in cirrhosis, cardiopathy, diabetes, endocrine dysfunctions arthropathy and susceptibility to liver cancer.
Database accession numbers
Revised June 25, 2008