TFR2 TFR2 (transferrin receptor 2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Liver
Spleen
Lung
Skeletal muscle
Prostate
Mononuclear Cell

Expression
TFR1 is expressed in the liver.  The α isoform is expressed in spleen, lung, muscle, prostate and peripheral mononuclear cells and the β isoform is weakly expressed in all tissues.


Structure

MOLECULAR FAMILY NAME:  Belongs to the peptidase M28 family.

TFR2 is single-pass type-2 glycoprotein.  It contains a protease associated (PA) domain, a M28 peptidase domain and a tranferrin domain receptor-like dimerization domain.  Two isoforms have been identified.  The α isoform is an 801 aa glycoprotein which contains an extracellular domain, a transmembrane domain and a cytoplasmic domain.  The β isoform lacks the amino-terminal portion of the α isoform including the transmembrane domain and is probably is intracellular.  TFR2 is a member of the transferrin receptor-like family.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isofoms (α, β, γ).

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TFR2: No information.

Function
TFR2 mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner.  It may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TFR2 IN INTACT ANIMAL

Defects in TFR2 cause a hereditary hemochromatosis type-3 (HFE3) which results in iron overload and can cause complications in cirrhosis, cardiopathy, diabetes, endocrine dysfunctions arthropathy and susceptibility to liver cancer.

Comments

MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TFR2: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TFR2: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 7036Q9UP52
Antibodies

Revised June 25, 2008


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