TM7SF4 TM7SF4 (transmembrane 7 superfamily member 4), DC-STAMP (dendritic cell-specific transmembrane protein)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Multi-pass
Lymph Node
Lung
Kidney
Liver
Dendritic Cell

Expression

TM7SF4 is highly expressed in lymph nodes, lung, kidney and liver.  Expression is at the low level in pancreas, bone marrow, spleen, leukocytes, peripheral blood mononuclear cells and B cells.  DC-STAMP expression is in dendritic cells, in both immature and mature DCs.  There is no expression in freshly isolated monocytes.



Structure
MOLECULAR FAMILY NAME: Belongs to the transmembrane 7 superfamily.

TM7S4 is a multi-pass 470 aa glycoprotein.  It contains a signal sequence, an extracellular domain which contains 3 potential N-linked glycosylation sites and a protein kinase C phosphorylation site, 7 putative transmembrane domains and a 72 aa cytoplasmic domain contains multiple serines, 2 of which could be phosphorylation domains.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields several different isoforms by the full length has not been determined.

POST-TRANSLATIONAL MODIFICATION

TM7SF4 has 3 N-linked glycosylation sites and a phosphorylation site.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TM7S4: No information.

Function
Dendritic cells are unique in their ability to present antigen to naive T cells, therefore playing a central role in the iniatiation of immune responses.  DC-STAMP expression is down regulated by ligation of the CD40 molecule.

TM7S4 plays an essential role in TNFSF11-mediated osteoclastogenesis and is involved in inducing the expession of tartrate-reistant phosphatase in osteoclast precursors.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TM7S4 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TM7SF4: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TM7SD4: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez81501Q9H295
Antibodies

Revised June 25, 2008


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