|TNFSF15||TNFSF15 (tumor necrosis factor (ligand) superfamily member 15), VEGI|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|TNFSF15 is expressed in endothelial cells but is not expressed in B or T cells It is also detected in placenta, lung, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.|
|MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor family.|
TNFSF15 is a single-pass type-2 174 aa glycoprotein. It contains an extracellular C terminus domain, a transmembrane domain and a short cytoplasmic domain.
POST-TRANSCRIPTIONAL MODIFICATION : No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH TNFSF15: No information.|
|Members of the TNF and TNFR superfamilies regulate biologic functions including cell proliferation, immune regulation and inflammation. The protein which encodes TNFSF15 is a cytokine which is a ligand for receptor TNFRSF25 and decoy receptor TFRSF21/DR6.|
It can activate NF-κB and MAP kinases and act as an autocrine factor to induce apoptosis in endothelial cells. The cytokine is found to inhibit endothelial cell proliferation and thus may function as an angiogenesis inhibitor.
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF TNFSF15 IN INTACT ANIMAL
TNFSF15 plays a role in colon carcinomas and inflammatory bowel disease.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TNFSF15: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY TNFSF15: No information.
Database accession numbers
Revised June 25, 2008