TNFSF15 TNFSF15 (tumor necrosis factor (ligand) superfamily member 15), VEGI
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Endothelial Cell
Placenta
Lung
Kidney
Skeletal muscle
Prostate
Colon
Pancreas
Spleen

Expression
TNFSF15 is expressed in endothelial cells but is not expressed in B or T cells  It is also detected in placenta, lung, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor family.

TNFSF15 is a single-pass type-2  174 aa glycoprotein.  It contains an extracellular C terminus domain, a transmembrane domain and a short cytoplasmic domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION : No information.

POST-TRANSLATIONAL MODIFICATION: No information.





Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TNFSF15: No information.

Function
Members of the TNF and TNFR superfamilies regulate biologic functions including cell proliferation, immune regulation and inflammation.  The protein which encodes TNFSF15 is a cytokine which is a ligand for receptor TNFRSF25 and decoy receptor TFRSF21/DR6.
It can activate NF-κB and MAP kinases and act as an autocrine factor to induce apoptosis in endothelial cells.  The cytokine is found to inhibit endothelial cell proliferation and thus may function as an angiogenesis inhibitor.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TNFSF15 IN INTACT ANIMAL

TNFSF15 plays a role in colon carcinomas and inflammatory bowel disease.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TNFSF15: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TNFSF15: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 9966O95150
Antibodies

Revised June 25, 2008


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