TNFRSF25 TNFRSF25 (tumor necrois factor receptor superfamily, member 25), DR3, LARD, TRAMP, APO-3
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Lymphocyte
Thymocyte
Thymus
Colon
Prostate
Small intestine
Spleen

Expression
TNFRSF25 is expressed in thymocytes, lymphocytes and in lymphocyte-rich tissues such as thymus, colon, intestine, prostate and spleen.

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor family.

TNFRSF25 is a single-pass type-1 417 aa glycoprotein.  It contains a signal sequence, an extracellular domain which contains 4 TNFR cysteine-rich domains, a transmembrane domain and a cytoplasmic domain which has a death domain which signals apoptosis.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 12 different isoforms.  Isoforms 1, 2, 9, and 11 are a single-pass type-1 membrane protein and isoforms 3-8, 10 and 12 are secreted proteins.

POST-TRANSLATIONAL MODIFICATION

TNFRSF25 has N-linked glycosylation sites.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TNFRSF25: No information.


Function

TNFRSF25 is a receptor for CD255 (TNFSF12/APO3L/TWEAK).  It interacts directly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades activation of NK-κB and induces apoptosis.  It may have a role in relating lymphocyte homeostasis.  The signal transduction of TNFRSF25 is mediated by various death domain containing adaptor proteins.  Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus.  Splicing of TNFRSF25 in B and T cells encounters a progammed change upon T cell activation, which predominantly produces full length, membrane bound isoforms and is thought.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TNFRSF25 IN INTACT ANIMAL: No information.



Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TNFRSF25: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TNFRSF25: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8718Q93038
Antibodies

Revised June 25, 2008


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