TREM1 TREM1 (triggering receptor expressed on myeloid cells 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Liver
Lung
Spleen
Lymph Node
Spinal cord
Placenta
Heart
Peripheral blood
Leukocyte

Expression
TREM1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue.  It is expressed in the lymph node, placenta, spinal cord and heart tissues.  It is more elevalted in peripheral blood leukocytes than in bone marrow and in normal cells than malignant cells.  Expression is low in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes.  Expression is also strong in acute inflammatory lesions caused by bacteria and fungi.  Isoform 2 was detected in the lung, liver and mature monocytes.

Structure

MOLECULAR  FAMILY NAME: Belongs to the immunoglobulin gene family.

TREM1 is a single-pass type-1 234 aa glycoprotein.  It contains a hydrophobic signal sequence, an extracellular domain which contains 1 Ig-like V-type domain and 3 potential N-linked glycosylation sites, a transmembrane domain with a charged lysine residue and a 5 aa cytoplasmic domain with no signaling motifs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative slicing yields 2 different isoforms.  Isoform 1 is cell membrane protein and isoform 2 is a secreted protein.

POST-TRANSLATIONAL MODIFICATION

TREM1 has 3 N-linked glycosylation sites..



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TREM1: No information.

Function
TREM1 triggers secretion of IL-8, monocyte chemotactic protein-1 and TNF-α and induces neutrophil degranulation.  Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ.  To mediate activation, TREM1 associates with the transmembrane adapter molecule DAP12.  Thus, TREM1 mediates activation of neutrophil and monocytes and may have a predominant role in inflammatory responses.  TREM1 also triggers release of pro- inflammatory chemokines and cytokines as well as increased surface expression cell activation markers. 

BIOCHEMCIAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TREM1 IN INTACT ANIMAL

TREM1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infection and is a crucial mediator of septic shock. 



Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TREM1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TREM1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene54210Q9NP99
Antibodies

Revised June 25, 2008


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