|TREM2||TREM2 (triggering receptor expressed on myeloid cells 2)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|TREM2 is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the central nervous system strong expression is in basal ganglia, coprpus callosum, medulla oblongata and spinal cord.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
TREM2 is single-pass type-1 230 aa glycoprotein. It contains an extracellular domain which contains 1 Ig-like V-type domain, a transmembrane domain and a cytoplasmic domain.
Alternative splicing yields 3 different isoforms. Isoform 1 is a membrane protein and isoform 2 and 3 are secreted proteins.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH TREM2: No information.|
TREM2 may have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. It forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
PROTEINS AND DNA ELEMENTS WHICH REGULATE OF TRANSCRIPTION OF TREM2: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY TREM2: No information.
Database accession numbers
Revised June 25, 2008