TREM2 TREM2 (triggering receptor expressed on myeloid cells 2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Macrophage
Dendritic Cell
Nervous system
Basal ganglia
Corpus callosum
Medulla oblongata

Expression
TREM2 is expressed on macrophages and dendritic cells but not on granulocytes or monocytes.  In the central nervous system strong expression is in basal ganglia, coprpus callosum, medulla oblongata and spinal cord.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

TREM2 is single-pass type-1 230 aa glycoprotein.  It contains an extracellular domain which contains 1 Ig-like V-type domain, a transmembrane domain and a cytoplasmic domain. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.  Isoform 1 is a membrane protein and isoform 2 and 3 are secreted proteins.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH TREM2: No information.

Function

TREM2 may have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.  It forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF TREM2 IN INTACT ANIMAL

Defects in TREM2 are a cause of polycystic of polycystic lipomembranous osteodysplasis with sclerosing leukoencephalopathy (PLOSL) which is also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD).  PLOSL is an inherited disease which causes dementia and bone cysts.  Data suggests that TYROBP mediated signaling pathway plays a significant role in the human brain and bone tissue.



Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE OF TRANSCRIPTION OF TREM2: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY TREM2: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene54209Q9NZC2
Antibodies

Revised June 25, 2008


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