XLKD1 XLKD1 (extracellular link domain containing 1), HAR (hyaluronan receptor), LYVE (lymphatic vessel endothelial hyaluronan receptor 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Endothelial Cell

Expression
XLKD1 is mainly expressed in endothelial cells lining lymphatic vessels.

Structure
MOLECULAR FAMILY NAME

XLKD1 is a single-pass type-1 322 aa glycoprotein.  It contains a leader sequence, a 212 aa extracellular domain which contains 7 cysterine aa, a putative link module marked by 4 conserved cysteines a serine/threonine-rich domains and 2 potential N-linked glycosylation sites, a 21 aa transmembrane domain and a 63 aa cytoplasmic domain.  XLKD1 is localized to the plasma membrane and in vessels near the extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes.prelysosomeal compartments.  It undergoes ligand-dependent internatization and recylcing at the cell surface.  It is a homodimer and disulfide-linked.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

XLKD1 has 2 potential N-linked glycosylation.

Ligands
LIGANDS AND MOLECULES ASSOCIATES XLKD1: No information.

Function
XLKD1 is a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane.  It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS).  XLKD1 binds to both soluble and immobilized hyaluronan and may act as a hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent up-take and degradation in lymph nodes. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF XLKD1 IN INTACT ANIMAL

XLKD1 may function in lymphatic hyaluronan transport and have a role in tumor metastasis.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCIPTION OF XLKD1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY XLKD1: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10894Q9Y5Y7
Antibodies

Revised June 25, 2008


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