|XLKD1||XLKD1 (extracellular link domain containing 1), HAR (hyaluronan receptor), LYVE (lymphatic vessel endothelial hyaluronan receptor 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|XLKD1 is mainly expressed in endothelial cells lining lymphatic vessels.|
|MOLECULAR FAMILY NAME|
XLKD1 is a single-pass type-1 322 aa glycoprotein. It contains a leader sequence, a 212 aa extracellular domain which contains 7 cysterine aa, a putative link module marked by 4 conserved cysteines a serine/threonine-rich domains and 2 potential N-linked glycosylation sites, a 21 aa transmembrane domain and a 63 aa cytoplasmic domain. XLKD1 is localized to the plasma membrane and in vessels near the extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes.prelysosomeal compartments. It undergoes ligand-dependent internatization and recylcing at the cell surface. It is a homodimer and disulfide-linked.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
XLKD1 has 2 potential N-linked glycosylation.
|LIGANDS AND MOLECULES ASSOCIATES XLKD1: No information.|
|XLKD1 is a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). XLKD1 binds to both soluble and immobilized hyaluronan and may act as a hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent up-take and degradation in lymph nodes. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF XLKD1 IN INTACT ANIMAL
XLKD1 may function in lymphatic hyaluronan transport and have a role in tumor metastasis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCIPTION OF XLKD1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY XLKD1: No information.
Database accession numbers
Revised June 25, 2008