|CD65||Ceramide dodecasaccharide 4c|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|CD65 is restricted to the myeloid lineage, with expression on most granulocytes, a proportion of monocyte cells, AML blasts and some ALL blasts. T and B cells, thymocytes, platelets and non-hematopoietic cells do not express CD65.|
|MOLECULAR FAMILY NAME: |
CD65 mAbs bind to a ceramide dodecasaccharide. The antigen consists of the oligosaccharide sequence without the terminal sialic acid. The epitopes are carried by various glycolipids and glycoproteins.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD65|
CD65 is a potential ligand for CD62E and CD62L.
|One study has implicated CD65 as a critical adhesion molecule for extravascular AML infiltration.|
BIOCHEMICAL ACITIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD65 IN INTACT ANIMAL: No information.
|CD65 was retained as a provisional CDw antigen at the Fifth Leukocyte Typing Workshop because of the heterogeneity of the CD65 mAbs in terms of cellular and antigenic reactivity. Since the CD65 mAbs have now been separated into 2 groups and their precise epitopes determined, the VIM-2 mAb has been replaced in a new cluster named CD65s.|
PROTEINS AND DNA ELEMENTS WHICH TRANSCRIPTION OF CD65: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD65: No information.
Database accession numbers
Revised June 25, 2008