CD65 Ceramide dodecasaccharide 4c
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Granulocyte
Monocyte
Myeloid Cell
AML Blast
ALL blast

Expression
CD65 is restricted to the myeloid lineage, with expression on most granulocytes, a proportion of monocyte cells, AML blasts and some ALL blasts.  T and B cells, thymocytes, platelets and non-hematopoietic cells do not express CD65.

Structure
MOLECULAR FAMILY NAME:

CD65 mAbs bind to a ceramide dodecasaccharide.  The antigen consists of the oligosaccharide sequence without the terminal sialic acid.  The epitopes are carried by various glycolipids and glycoproteins.

MOLECULAR MASS
Cell Type Unreduced Reduced

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD65

CD65 is a potential ligand for CD62E and CD62L.

Function
One study has implicated CD65 as a critical adhesion molecule for extravascular AML infiltration.

BIOCHEMICAL ACITIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD65 IN INTACT ANIMAL: No information.


Comments
CD65 was retained as a provisional CDw antigen at the Fifth Leukocyte Typing Workshop because of the heterogeneity of the CD65 mAbs in terms of cellular and antigenic reactivity.  Since the CD65 mAbs have now been separated into 2 groups and their precise epitopes determined, the VIM-2 mAb has been replaced in a new cluster named CD65s.

MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH TRANSCRIPTION OF CD65: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD65: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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