CD70 CD27-Ligand, KI-24 antigen
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
T Cell
B Cell
NK Cell
Leukemia cell
50 / 50

Expression
CD70 is expressed on most activated B cells and some activated T cells but is absent on resting lymphocytes, red blood cells, thymocytes, platelets, monocytes, neutrophils, and dendritic cells.  CD70 is expressed on B cell chronic lymphocytic leukemias and large B cell lymphomas.  CD70 is expressed on lymphocytes as a co-stimulatory molecule involved in differentiation and proliferation and is expressed on stimulated NK cells increasing their ability to interact with their targets.  CD70 is found on glanular epithelium and endothelium in all of the proliferative phase cases but the secondary phase expression is decreased.

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor superfamily.

CD70 is a single-pass type-2 193 aa glycoprotein.  It contains an 155 aa extracellular C-terminal domain which contains 2 potential N-glycosylation sites, an 18 aa transmembrane domain and a 20 aa cytoplasmic domain.  CD70 forms a trimeric structure.

MOLECULAR MASS
Cell Type Unreduced Reduced
50kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD70

CD70 binds CD27, a member of the TNFR superfamily.

Function
CD70 plays a role in T cell activation, inducing proliferation co-stimulated T cells and enhances the generation of cytotoxic T cells and cytokine production.  CD70 is involved in the generation and long term maintenance of T cell memory, particularly in CD8+ cells.  It plays a role in expansion and differentiation of B cells and plasma cell differentiation.  CD70 binding to CD27 on B cells co-stimulates B cell proliferation and immunoglobulin production.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD70 IN INTACT ANIMAL

Identification of CD70-mediated apoptosis of immune effector cells provides a novel immune escape pathway of human glioblastoma.


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD70: No information

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD70: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 970P32970
Antibodies
HNE.51   View Reactivity
Ki-24   View Reactivity

Revised June 25, 2008


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