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Generally, the basophilic granules of the basophil will obscure the nucleus. The lighter basophilic lobed structure is the nucleus. Because these cells were stained with Wright's stain instead of H&E, the nucleus may appear more acidophilic than what we expect with H&E.  Basophils are rare in the peripheral blood (<1% of all leukocytes), and an increase (basophilia) does not generally occur without a concurrent increase in eosinophils (eosinophilia).

As with the other granulocytes, the basophil has a segmented nucleus, although it is often obscured by the basophilic granules. What is contained in the granules of a basophil?